Everton midfielder Marouane Fellaini begins a three-match ban against the Gunners following his sending-off in the draw with Bolton in midweek.
However, John Heitinga could return after missing out on Wednesday with a minor knee problem while Jack Rodwell (ankle) is getting closer to a start after three games as an unused substitute.
Victor Anichebe (knee), Leon Osman (ankle) and Ross Barkley (broken leg) remain on the sidelines.
England left-back Kieran Gibbs returns to the Arsenal squad but goalkeeper Manuel Almunia (elbow), centre-half Thomas Vermaelen (Achilles), midfielder Abou Diaby (ankle) and defender Laurent Koscielny (suspension) remain unavailable, while Aaron Ramsey continues his rehabilitation following a broken leg.
Theo Walcott and Samir Nasri could come back into the starting XI, having been left on the bench for the midweek victory at Wolves.
Everton (from): Howard, Neville, Distin, Jagielka, Baines, Coleman, Cahill, Heitinga, Pienaar, Arteta, Saha, Hibbert, Bilyaletdinov, Rodwell, Beckford, Yakubu, Gueye, Silva, Baxter, Duffy, Mucha.
Arsenal (from): Fabianski, Clichy, Squillaci, Djourou, Sagna, Arshavin, Fabregas, Song, Wilshere, Rosicky, Chamakh, Szczesny, van Persie, Eboue, Walcott, Nasri, Denilson, Bendtner, Gibbs.