Liverpool striker Andy Carroll could return to the squad.
The £35million record signing has missed two of the last three matches with a knee injury sustained at Arsenal in mid-April but trained this week and may take his place on the bench.
Midfielder Raul Meireles was forced off with a minor injury in Monday's 5-2 demolition of Fulham but has also trained with the squad.
Tottenham defender William Gallas will miss out with a calf injury which looks to have ended his season.
Ledley King could feature at Anfield, though, after making a successful comeback from his groin problem during a practice match in midweek.
Gareth Bale (ankle), Benoit Assou-Ekotto (hamstring), Heurelho Gomes (back) and Jermaine Jenas (thigh) are definitely out.
Liverpool (from): Reina, Johnson, Carragher, Skrtel, Flanagan, Lucas, Spearing, Meireles, Rodriguez, Kuyt, Suarez, Gulacsi, Kyrgiakos, Wilson, Robinson, Poulsen, Shelvey, Cole, Carroll.
Tottenham (from): Cudicini, Pletikosa, Bassong, Dawson, Kaboul, King, Corluka, Lennon, Kranjcar, Pienaar, Sandro, Modric, Rose, Kranjcar, Van der Vaart, Defoe, Pavlyuchenko, Crouch.