The former Hartlepool centre-half picked up an ankle injury in the closing stages of Saturday's 2-0 win over Swansea and is set for a scan.
Dane Jens Berthel Askou is poised to make his first start of the campaign alongside Elliott Ward at the heart of the back four.
Manager Paul Lambert has also pledged to make a few changes to keep his squad fresh.
Midfielders Simon Lappin and David Fox are likely to start while striker Simeon Jackson could be given a chance in attack after he came off the bench to score his first goal for the club on Saturday.
Former Rangers left-back Steven Smith will have to wait for his first start as he is still recovering from an ankle injury while fellow defender Zak Whitbread is still not ready.
