Midfielder Frank Lampard will miss the clash with the French side as well as England's European Championship clash with Montenegro.
Lampard still requires more time to recover from hernia surgery and has now been pencilled in for a return after the international break.
Ivory Coast striker Didier Drogba sits out the last of his two-match ban against his former side.
Chelsea are also without injured Salomon Kalou (thigh) and Yossi Benayoun (calf), but Gael Kakuta has recovered from his back injury.
Marseille boss Didier Deschamps insists his side must be on top form if they are to get any reward from their Champions League clash at Stamford Bridge.
Deschamps returns to his former club boosted by two league victories but he is acutely aware Marseille cannot afford to make any mistakes against a Chelsea side smarting from two successive defeats.
Having lost their opening game to Spartak Moscow, Deschamps knows it is imperative they get something from their trip to west London.
"Winning two games does not so much give us a guarantee but a calmness going into this game," said Deschamps. "It is a bigger task taking on a team like Chelsea.
"We have got to go into this game making no mistakes and playing at our top level.
"Chelsea have had a good start to the season but they have not played many sides from the upper echelons of the league.
"I did watch the game against Manchester City, who did a lot of good things that hopefully we can repeat.
"We need to close the space down and impose ourselves physically. These kind of games are settled in the finer details and let us hope it is settled in our favour.
"Chelsea at home in a European tie against most teams would be favourites. There are a lot of experienced heads in their team. They can cope with two defeats. But we are not here just to watch them play."
Deschamps, who turned down the chance to join Liverpool in the summer, spent a year with Chelsea in 2000 - leaving the club on a high by winning the FA Cup.
But he accepts that today's Chelsea bears little resemblance to the one he knew.
"It is totally different to when I was here," added Deschamps. "Roman Abramovich was not here during my time at the club, we had a different owner then.
"Roman has brought in lots of investment in terms of players and the training ground at Cobham, we did not have anything like that. All these things have added another dimension to the club. It has allowed them to take a seat at the top table of European football.
"I have great memories of my time here, it was a short stay, just one year. I spent five years playing for Juventus in Turin and it took time for me to settle in.
"It was great to round it off with a win at Wembley in the FA Cup final in the last one at the old stadium. That was a great way to finish my time here."
Meanwhile, Marseille striker Loic Remy is hoping to help make it a week to forget for Ancelotti.
Remy, who was a target for Tottenham before joining Marseille from Nice for £13.7million in the summer, said: "We took a lot of confidence from beating Sochaux 2-1 on Saturday night and we know that Chelsea have had two losses. Now it's up to us to go there and to not be shy.
"We are going to London to play our game with a calm state of mind and to make the same significant physical impact as we did against Sochaux. We'll go over there to play hard.
"It will not be a cakewalk but if we play to our strengths we can cause a surprise. We know we will have to defend well because they are going to attack our goal all game long."
Blues (from): Cech, Ivanovic, Terry, Alex, Cole, Ramires, Mikel, Essien, Anelka, Borini, Kakuta, Malouda, Ferriera, Bruma, Zhirkov, Sturridge, Turnbull, Van Aanholt, McEachran.