The Blues will be without France winger Florent Malouda when Spartak arrive in West London.
Malouda collected an ankle injury in the win over Blackburn and will miss out along with England midfielder Frank Lampard (groin) and Jose Bosingwa (illness).
Yossi Benayoun remains a long-term absentee with an Achilles problem but Brazilian midfielder Ramires is fit again after an ankle injury.
Chelsea (from): Cech, Turnbull, Hilario, Ivanovic, Terry, Cole, Alex, Ferreira, Obi, Essien, Ramires, Zhirkov, Drogba, Anelka, Kalou, Kakuta, McEachran, Van Aanholt, Bruma, Sturridge, Borini.
