Liverpool striker Fernando Torres is set to make his first Europa League appearance of the season but captain Steven Gerrard has not made the trip to Holland.
Gerrard and defender Daniel Agger are the only two senior players left at home as manager Roy Hodgson names a strong squad for their second Group K fixture.
Agger's absence, coupled with Paul Konchesky's hamstring injury and Fabio Aurelio's on-going Achilles tendon problem, means Martin Kelly is likely to be forced into action as an emergency left-back.
Holland forward Dirk Kuyt, who made a comeback from a shoulder injury at the weekend, is set to face his former club.
Liverpool (from): Reina, Johnson, Skrtel, Carragher, Kelly, Poulsen, Lucas, Meireles, Kuyt, Cole, Torres, Jones, Kyrgiakos, Shelvey, Rodriguez, Spearing, Babel, Jovanovic, Eccleston, Ngog.