Murphy has started both of the cup games this season, against Exeter and Crewe, and will replace first-choice Martin Fulop for the trip.
Boss Roy Keane has admitted further changes will be made as he attempts to keep his squad fresh and that could mean starts for Mark Kennedy, Colin Healy and Thamas Priskin with Darren O'Dea, Jason Scotland and Connor Wickham possibly dropping to the bench.
Long-term absentees Luciano Civelli and Damien Delaney have featured for the reserves after overcoming a knee injury and a blood clot respectively and could make the bench but Shane O'Connor remains sidelined with a hamstring injury.
