Mouyokolo moved from Hull during the summer in a £2.5million deal but has been laid low with ankle and hamstring injuries.
He will be partnered by Christophe Berra who missed the 3-1 defeat at Tottenham at the weekend through suspension.
Striker Marcus Bent, who is on loan from Birmingham, has been handed his first start by manager Mick McCarthy who has named his starting line-up.
McCarthy has made nine changes from the side beaten at White Hart Lane with only Richard Stearman and Kevin Foley retaining their places.
Team: Hennessey, Stearman, Berra, Mouyokolo, Elokobi, Milijas, Foley, Guedioura, Halford, Bent, Ebanks-Blake.
Subs (from): Hahnemann, Ward, Mancienne, Craddock, Jarvis, Van Damme, Henry, Doyle, D Jones, Fletcher.