Liverpool manager Roy Hodgson is set to revert to his strongest line-up for the visit of Rovers after resting a number of players in midweek.
Fernando Torres, Steven Gerrard, Raul Meireles and Lucas Leiva are all set to return after being left at home for the Europa goalless draw against Napoli in Italy.
Defender Jamie Carragher came off at half-time in that game and needs to be given the all-clear to play but right-back Glen Johnson is set to return after missing the last two games with a hamstring problem.
Centre-back Daniel Agger missed the trip because of illness but could come back into the squad.
Forward Dirk Kuyt is still at least a couple of weeks away from returning from an ankle injury.
Christopher Samba is suspended for Blackburn but Ryan Nelsen may have recovered from a thigh injury picked up on international duty.
Keith Andrews (groin), Jason Roberts (ankle) and Vince Grella (hamstring) are out.
New recruit Herold Goulon, who this morning signed a two-year deal after a successful trial period, will not feature as he awaits international clearance.
Liverpool (from): Reina, Johnson, Carragher, Skrtel, Konchesky, Poulsen, Gerrard, Meireles, Cole, Torres, Ngog, Jones, Aurelio, Kyrgiakos, Lucas, Kelly, Jovanovic, Rodriguez, Babel, Agger.
Blackburn (from): Robinson, Nelsen, Salgado, Jones, Givet, Olsson, Nzonzi, Pedersen, Dunn, Emerton, EH Diouf, MB Diouf, Kalinic, Benjani, Bunn, Chimbonda, Hoilett, Linganzi.