MK Dons boss Karl Robinson will be without defender Gary MacKenzie for the Johnstone's Paint Trophy southern section second-round clash.
The centre-half - who has just returned from an injury sustained in the summer - limped out of the 1-1 draw with Colchester on Saturday after just 21 minutes with a groin injury and will miss out.
Adam Chicksen came off the bench to replace him but Robinson may choose to reinstate the experienced figure of Sean O'Hanlon instead after he recovered from a slight injury.
Angelo Balanta was a substitute on his return from a hamstring injury at the weekend and came on to score the equaliser for the Dons and is in contention to start.
Striker Sam Baldock is still out with an ankle injury and midfielder Stephen Gleeson rounds out the injury list as he continues to struggle with a back muscle problem.
Matt Fry is an injury doubt for Charlton ahead of their Johnstone's Paint Trophy trip to MK Dons.
The former West Ham defender limped off at half-time during Saturday's defeat at Brentford and needs a late check.
Johnnie Jackson started on the wing at Griffin Park but reverted to left-back when Fry was forced off and could stay in defence with Kyel Reid starting in front of him.
Veteran defender Christian Dailly was an unused substitute after a month out recovering from a fractured eye socket and he could feature.
Striker Joe Anyinsah remains doubtful with the back injury which has sidelined him for two games, while Alan McCormack (calf), Chris Solly (ankle) and Kelly Youga (knee) are still missing.
The match kicks off at 7.15pm.