Newcastle boss Chris Hughton will ring the changes once again as he attempts to secure a place in the Carling Cup quarter-finals at the expense of Arsenal.
Hughton will rest several of his key men ahead of Sunday's derby clash with Sunderland, with striker Andy Carroll among those likely to be left out.
Tamas Kadar, Shane Ferguson and Haris Vuckic, who have been involved in the earlier rounds, are in line for starts, although Sol Campbell (thigh) will miss out and the game will come too soon for Steven Taylor (shoulder) despite his return to full training.
Steve Harper (shoulder), Leon Best (ankle), Hatem Ben Arfa (double leg fracture) and Dan Gosling (knee) are still sidelined.
Arsene Wenger is again likely to select a strong squad for the trip to Newcastle.
Nicklas Bendtner and Theo Walcott are both fit following injury and could feature after coming off the bench in the 3-0 Premier League win over 10-man Manchester City, while youngsters Jay Emmanuel-Thomas, Kieran Gibbs, Henri Lansbury - who scored in the last round at White Hart Lane - and goalkeeper Wojciech Szczesny will probably be included again.
Centre-half Laurent Koscielny has recovered from a back problem, but Thomas Vermaelen (Achilles), Robin van Persie (ankle), Manuel Almunia (elbow) and Aaron Ramsey (leg) are still sidelined, while England midfielder Jack Wilshere continues to serve a three-match ban.
Newcastle (from): Krul, Soderberg, R Taylor, Simpson, Perch, Ferguson, Enrique, Coloccini, Williamson, Kadar, Smith, Tiote, Barton, Routledge, Gutierrez, Guthrie, Vuckic, Tavernier, Donaldson, Nolan, Carroll, Ameobi, Lovenkrands, Ranger.
Arsenal (from): Szczesny, Gibbs, Djourou, Koscielny, Eboue, Rosicky, Denilson, Diaby, Lansbury, Bendtner, Walcott, Fabianski, Clichy, Squillaci, Arshavin, Song, Fabregas, Nasri, Chamakh, Emmanuel-Thomas, Eastmond.