Sir Alex Ferguson has reported a clean bill of health ahead of their top-of-the-table duel.
Rio Ferdinand and Paul Scholes have returned to training after hamstring and groin problems respectively, while Jonny Evans and Wes Brown have recovered from a virus.
It is United's first league outing since smashing seven goals past Blackburn and they are bidding to extend a five-match unbeaten run against the Gunners.
Arsenal will leave it as a late as possible to decide on the fitness of captain Cesc Fabregas (hamstring).
Full-back Kieran Gibbs is out after injuring his ankle in the midweek Champions League win over Partizan Belgrade, but both Gael Clichy (virus) and Johan Djourou (thigh) should travel to Old Trafford.
Goalkeeper Manuel Almunia (elbow), centre-back Thomas Vermaelen (Achilles) and midfielder Abou Diaby (ankle) remain out.
United (from): Van der Sar, Kuszczak, Amos, Rafael, O'Shea, Ferdinand, Vidic, Smalling, Brown, Evans, Evra, Fabio, Nani, Park, Carrick, Scholes, Anderson, Obertan, Giggs, Rooney, Berbatov, Hernandez, Macheda, Bebe.
Arsenal (from): Fabianski, Sagna, Squillaci, Djourou, Eboue, Arshavin Song, Wilshere, Nasri, van Persie, Chamakh, Szczesny, Denilson, Rosicky, Koscielny, Walcott, Bendtner, Clichy, Fabregas.