Bolton have Paul Robinson back but are still missing a number of players.
Robinson is available again after serving a one-match suspension but it is thought that the game will be too soon for injured pair Stuart Holden and Gretar Steinsson.
Lee Chung-yong remains on international duty with South Korea while Tamir Cohen is not expected to return for this fixture following the death of his father.
Joey O'Brien, Sean Davis, Ricardo Gardner and Jlloyd Samuel are all absent too.
Wigan will again be without the suspended Charles N'Zogbia.
Antolin Alcaraz looks likely to retain his place at the back after showing no ill-effects from a previous thigh injury when playing 90 minutes in the defeat to Newcastle on Sunday.
New signing Adrian Lopez, the former Spain Under-21 international and Deportivo La Coruna defender, is expected to be on the bench.
Bolton (from): Jaaskelainen, Robinson, Bogdan, Cahill, Knight, Muamba, Petrov, K Davies, Elmander, Blake, Taylor, Klasnic, Ricketts, Alonso, Moreno, M Davies.
Wigan (from): Al Habsi, G Caldwell, Gohouri, Stam, Figueroa, Alcaraz, Lopez, Watson, Diame, McArthur, Cleverley, Thomas, Rodallega, Boselli, Gomez, McManaman, S Caldwell, Golobart, Mustoe, Pollitt.