Arsenal could welcome back Emmanuel Eboue ahead of schedule from a knee problem for the last-eight visit of Latics.
Centre-half Sebastien Squillaci picked up a minor knee problem during Saturday's win at Aston Villa and captain Cesc Fabregas (hamstring) remains sidelined along with Abou Diaby (ankle) and Thomas Vermaelen (Achilles).
Robin van Persie, Theo Walcott and Nicklas Bendtner could all feature having been unused substitutes at Villa Park, while manager Arsene Wenger must decide whether to recall fit-again goalkeeper Manuel Almunia or give young Pole Wojciech Szczesny another chance.
Antolin Alcaraz returns from a one-match suspension for Wigan.
Hugo Rodallega remains unavailable as he serves the second instalment of a three-game ban, while on-loan Manchester United midfielder Tom Cleverley is not eligible to play under the terms of his season-long deal.
Gary Caldwell (thigh), Emmerson Boyce (hamstring) and James McCarthy (ankle) remain on the sidelines.
Arsenal (from): Szczesny, Gibbs, Djourou, Koscielny, Eboue, Denilson, Song, Wilshere, Rosicky, Walcott, van Persie, Almunia, Arshavin, Chamakh, Nasri, Emmanuel-Thomas, Vela, Eastmond, Nordtveit, Clichy.
Wigan (from): Al Habsi, Stam, Gohouri, Alcaraz, Figueroa, Thomas, Diame, N'Zogbia, Gomez, Di Santo, Moses, McArthur, S Caldwell, Boselli, Di Santo, Watson, McManaman, Pollitt.