The Hammers will be without cup-tied defender Lars Jacobsen for the visit of the holders.
Midfielder Scott Parker could be rested as Irons boss Avram Grant looks to protect key men from burnout, but Kieron Dyer may return from a hamstring problem.
Mark Noble (hip) is set for another spell on the sidelines having only just returned from an appendix operation, while Manuel Da Costa (ankle), Thomas Hitzlsperger (thigh) and Jack Collison (knee) remain out.
United boss Sir Alex Ferguson is expected to make massive changes for the game against the Hammers.
Javier Hernandez, Chris Smalling and Wes Brown are amongst those who will hope to be involved, while a new goalkeeper is also expected as Edwin van der Sar stands down in favour of either Tomasz Kuszczak or Ben Amos.
Winners of the tournament for the past two seasons, United will expect a tough test against a Hammers side who recorded three successive wins over Ferguson's team prior to their present run of six victories on the trot.
West Ham (from): Green, Gabbidon, Reid, Upson, Tomkins, Kovac, Behrami, Barrera, Stanislas, Piquionne, Cole, Obinna, Stech, Boa Morte, Hines, McCarthy, Ben-Haim, Faubert, Ilunga, Dyer, Parker.
Man United (from): Kuszczak, Amos, Rafael, O'Shea, Brown, Ferdinand, Vidic, Evans, Smalling, Evra, Fabio, Morrison, Eikrem, Nani, Park, Carrick, Fletcher, Scholes, Anderson, Obertan, Giggs, Rooney, Hernandez, Macheda, Bebe.