Huddersfield will be without winger Anthony Pilkington, who passed a late fitness test ahead of Saturday's 1-0 defeat at Oldham, but pulled up shortly before half-time and was replaced by Scott Arfield.
Arfield was one of few players to impress at Oldham on Saturday and is expected to start in Pilkington's absence.
Winger Gary Roberts, who started on the bench as he works his way back from a broken arm, is also pushing for a start.
Manager Lee Clark has no other new injury or suspension problems for the clash with Cambridge, who earned a replay at the Galpharm Stadium following a goalless draw at the Abbey Stadium 10 days ago.
Long-term absentees Gary Naysmith (foot), Tom Clarke (knee) and Lee Novak (hamstring) are still out.