Mohamed Diame is rated 50-50 to return for Latics.
The midfielder missed the 1-1 draw at Aston Villa last time out with a groin injury but he will be given time to prove his fitness.
Otherwise, Roberto Martinez has an unchanged squad to choose from as his second-bottom side look for three points in their penultimate match of the season.
Scott Parker could feature for West Ham.
The England international has missed recent matches with an Achilles complaint but has returned to training and is likely to be involved in some way.
Other than midfielders Gary O'Neil (ankle) and Mark Noble (hernia), the Hammers have a full squad of players available to them.
Wigan (from): Al Habsi, G Caldwell, Gohouri, Alcaraz, Watson, Figueroa, N'Zogbia, Diame, Moses, McCarthy, Rodallega, Stam, Thomas, Gomez, McArthur, Cleverley, Sammon, Di Santo, Boyce, Kirkland.
West Ham (from): Green, Jacobsen, Tomkins, Upson, Hitzlsperger, Piquionne, Spector, Ba, Cole, Boffin, Reid, Da Costa, Boa Morte, Collison, Keane, Spence, Bridge, Parker, Stanislas.