Burnley caretaker boss Stuart Gray plans to send out a full-strength side for the game against Vale.
John Guidetti has been recalled by Manchester City at the end of his loan spell at Turf Moor.
The Sweden Under-21 international made two starts in five appearances for the Clarets during a month-long stay.
Yet Gray will field a strong side as he bids to avoid an embarrassing upset.
He said: "The pleasing thing is we have a clean bill of health. We have Danny Fox available for Saturday and we want to pick 11 who want to get through to the next round of the FA Cup.
"There's a good strength in depth there at the moment."
New Port Vale manager Jim Gannon starts his tenure with the trip to the Clarets.
The former Stockport, Motherwell and Peterborough boss was announced as Micky Adams' successor on Thursday morning and will take his place in the Vale dugout for the first time at Turf Moor.
However, Gannon will be without star striker Marc Richards and in-form midfielder Doug Loft.
Fourteen-goal frontman Richards, who would have been suspended for the clash in any case having received two yellow cards during Monday's win over Burton, sustained a Grade Two tear to a thigh muscle in the same game and is now facing six weeks on the sidelines.
Loft, meanwhile, missed the encounter altogether and scans have highlighted a tear to his calf so he will be missing for four weeks.
Goalkeeper Stuart Tomlinson is able to feature after his appeal against the red card he was shown at Rotherham on New Year's Day was successful.