Doncaster could be boosted by the return of George Friend, James Chambers, Martin Woods and Simon Gillett for the clash.
Friend has been sidelined since mid-October, fellow defender Chambers stepped off the substitutes' bench in Monday's draw at Sheffield United for his first appearance of the season and midfielder Gillett has missed the last 12 games.
All three players have been struggling with knee injuries - Chambers had surgery in the summer - and came through a midweek practice game against Scunthorpe unscathed.
Midfielder Woods also had a successful run-out following a long-term groin injury and is expected to return to the squad.
But Rovers will be without defender Dennis Souza, who sits out a one-game ban following his dismissal at Sheffield United on Monday.
Matt Doherty will make his Wolves debut in the game at Donny.
Minor ankle injuries to Kevin Foley and Ronald Zubar have given the 18-year-old a chance at right-back.
Manager Mick McCarthy will otherwise name a strong team for the match, although striker Sylvan Ebanks-Blake will be out for three weeks with a hamstring injury he picked up in Wednesday night's win over Chelsea.
Fellow frontman Kevin Doyle came off with cramp against the Blues as he made his return from a thigh injury, but should continue his comeback this weekend.
Marcus Hahnemann will play in goal as Wayne Hennessey is rested.
Wolves captain Karl Henry and defender Jody Craddock are still not ready to return following injury and Steven Mouyokolo is still out with an ongoing back complaint, while Michael Mancienne's knee problem rules him out.
Michael Kightly (knee) and Adlene Guedioura (leg) are long-term absentees.
Wolves (from): Hahnemann, Jarvis, Jones, Ward, Fletcher, Stearman, Mujangi Bia, Milijas, Elokobi, Hennessey, Hunt, Batth, Doyle, Doherty.