Arsenal will rotate their squad for the game against Leeds, where young midfielder Aaron Ramsey will be back in contention after returning from a loan spell at Nottingham Forest.
Emmanuel Eboue will come in at right-back for the suspended Bacary Sagna, while Kieran Gibbs is available again after an ankle injury.
Captain Cesc Fabregas, Jack Wilshere, Robin van Persie, Samir Nasri and Laurent Koscielny are all set to be rested, so the likes of Denilson, Craig Eastmond, Nicklas Bendtner and Tomas Rosicky should all start.
Midfielder Abou Diaby (calf), goalkeeper Manuel Almunia (ankle), Abou Diaby (calf) and centre-back Thomas Vermaelen (Achilles) remain out.
Leeds trio Sanchez Watt, Lloyd Sam and Andy O'Brien are doubtful for the game against the Gunners.
Striker Watt, on a season-long loan from the Gunners, has been given permission to play by Arsene Wenger but sustained a head injury after stepping off the bench in the midweek defeat at Cardiff, where he made only his second appearance since mid-October.
Midfielder Sam is nursing a thigh strain and central defender O'Brien has a dead leg.
Manager Simon Grayson said: "We're depleted somewhat by injury as it stands.
"We've had a lot of games in a short space of time and that has taken its toll. I'm not surprised, given the run we've had, so we'll take things as they come over the next day or so."
Grayson, whose side have played four games in 10 days, must decide whether to retain Ben Parker at left-back after the 23-year-old made his first appearance of the season following a series of injuries.
Arsenal (from): Szczesny, Eboue, Squillaci, Djourou, Gibbs, Eastmond, Denilson, Rosicky, Arshavin, Chamakh, Bendtner, Fabianski, Vela, Walcott, Ramsey, Henderson, Ignasi.