Hull will be without recent signing Aaron Mclean for their tie against the Latics.
The striker made his full debut in Monday's 3-2 win at Portsmouth but is cup-tied for the third-round tie having already appeared in the competition for Peterborough.
Another recent arrival, striker Matty Fryatt, is eligible following his permanent move from Leicester and could make his first start after stepping off the substitutes' bench to score on his debut at Portsmouth.
Robert Koren is back in contention following illness and could step in for Mclean but manager Nigel Pearson will be without fellow midfielder Tom Cairney, who is sidelined after burning himself on scolding water at home.
Defender Liam Rosenior sits out the second of a three-game ban, goalkeeper Vito Mannone has returned to parent club Arsenal due to a thigh injury and winger Richard Garcia has undergone knee surgery.
Pearson could hand a late fitness test to full-back Paul McShane, who is struggling with a shoulder injury.
Wigan manager Roberto Martinez is likely to take the opportunity to field a number of fringe players in the game.
Tom Cleverley has been ruled out for up to four weeks after sustaining a hamstring injury against Bolton in midweek.
Goalkeeper Chris Kirkland, who suffered a bang to the head in the same game, is not seriously injured but will not feature while Mauro Boselli (hamstring) will be out for seven days.
Emmerson Boyce (hamstring) is close to fitness but may not be risked while Charles N'Zogbia is suspended and James McCarthy, Victor Moses and Franco di Santo remain long-term absentees.
Wigan (from): Al Habsi, Pollitt, G Caldwell, Gohouri, Stam, Figueroa, Alacaraz, Watson, Diame, McArthur, Thomas, McManaman, Rodallega, Lopez, Gomez, S Caldwell, Robinson, Boyce, De Ridder, Golobart, Mustoe.