Carlton Cole looks set to return for the Hammers.
The England striker was one of several first-team players rested for the FA Cup win over Barnsley, so Scott Parker, centre-back Matthew Upson and forward Freddie Sears should also return.
Thomas Hitzlsperger has returned to training after a long-term thigh problem and he could be back in action by mid-February, but Kieron Dyer (thigh) remains out.
Birmingham will welcome back several key players.
Barry Ferguson, skipper Stephen Carr, Ben Foster, Roger Johnson and Liam Ridgewell were all rested for the 4-1 FA Cup win at Millwall on Saturday.
Midfielder Sebastian Larsson is included in the squad despite being given permission to speak to Newcastle over a possible move. Striker Matt Derbyshire will be hoping his two goals at the New Den will bolster his chances of starting against Avram Grant's side.
Midfielder Lee Bowyer will again be unavailable as he completes a three-match suspension.
West Ham (from): Green, Faubert, Upson, Tomkins, Gabbidon, Sears, Parker, Noble, Boa-Morte, Cole, Piquionne, Obinna, Hines, Edgar, Nouble, Behrami, Spence, Reid, Boffin.
Birmingham (from): Foster, Carr, Johnson, Dann, Ridgewell, Larsson, Gardner, Ferguson, Fahey, Hleb, Jerome, Zigic, Taylor, Beausejour, Derbyshire, Mutch, Phillips, Michel, Jiranek, Parnaby, Murphy.