Grant Leadbitter will miss the tie through suspension.
The former Sunderland midfielder will be absent as he serves the second of a three-match ban, but Celtic defender Darren O'Dea and Tottenham midfielder Jake Livermore have both been given permission to play by their parent clubs.
Captain Gareth McAuley should continue in the side following his recovery from an Achilles injury, but goalkeeper Brian Murphy will be out for at least three months with an ankle injury.
Winger Shane O'Connor also remains sidelined with a ruptured and dislocated shoulder and midfielder Luke Hyam (hamstring) complete a lengthy injury list.
Arsenal will be without centre-back Sebastien Squillaci (hamstring) and right-back Bacary Sagna, who is serving a three-match ban.
Wojciech Szczesny will continue in goal, while centre-half Laurent Koscielny is expected to return having been rested for the FA Cup third-round draw against Leeds, as could striker Robin van Persie and England midfielder Jack Wilshere.
Aaron Ramsey is in contention to start, and reserve-team captain Ignasi Miquel should again be in the squad as defensive cover.
Midfielder Abou Diaby (calf), goalkeeper Manuel Almunia (ankle) and centre-back Thomas Vermaelen (Achilles) remain out.
Arsenal (from): Szczesny, Eboue, Djourou, Koscielny, Gibbs, Arshavin, Song, Ramsey, Rosicky, Walcott, Bendtner, Fabianski, Van Persie, Chamakh, Fabregas, Clichy, Denilson, Miquel, Wilshere, Vela.