Eidur Gudjohnsen could make his first Fulham start against their west London rivals.
The Iceland striker made his Cottagers debut as a late substitute in the 2-2 draw against Aston Villa and will be pushing for a spot in the first XI against his former club.
Dickson Etuhu (hamstring) and Philippe Senderos (Achilles) are likely to miss out again, while Bobby Zamora is still two to three weeks away from fitness after recovering from a broken leg.
Chelsea manager Carlo Ancelotti has confirmed £25million signing David Luiz will be given his first start for the club at Fulham.
Centre-back Luiz is expected to come in for Jose Bosingwa, who has a knock, with Branislav Ivanovic moving to right-back.
In attack, the Italian looks set to persevere with a front three of £50million former Liverpool striker Fernando Torres, Didier Drogba and Nicolas Anelka.
Fulham (from): Schwarzer, Stockdale, Pantsil, Hangeland, Hughes, Baird, Briggs, Davies, Riise, Murphy, Sidwell, Duff, Dempsey, Gudjohnsen, Kakuta, Kamara, Gera, Dembele, Salcido, Greening, Johnson, Halliche.
Chelsea (from): Cech, Ferreira, Bosingwa, Terry, Ivanovic, Luiz, Cole, Mikel, Essien, Lampard, Ramires, McEachran, Kalou, Malouda, Torres, Anelka, Drogba, Turnbull.