Oldham boss Paul Dickov could name an unchanged side.
The Latics beat Swindon 2-0 at home on Saturday and came through with no fresh worries.
Dickov is hoping to re-sign defender Aidy White on loan from Leeds, but even if the deal is completed before the visit of Saints he may miss out anyway due to an ankle injury.
Oldham underlined their play-off credentials with a fine performance against the Robins at the weekend, which left Dickov delighted.
He said: "We said to the boys before the game keep doing the right things, but if we do the basics right we'll win more games than we lose and we did that.
"We coped very well with anything they had and as always we looked a threat going forward."
Kelvin Davis, Richard Chaplow and Jose Fonte are in line to return for Southampton.
Goalkeeper Davis and midfielder Chaplow were given the afternoon off and Fonte was on the bench as a much-changed Saints side beat Blackpool in the FA Cup on Saturday.
Boss Nigel Adkins made eight changes for the weekend clash and the 2-0 win will have given him a number of selection dilemmas.
Jason Puncheon should keep his place after impressing on his return from a loan spell with Millwall, even though the Lions want to sign him permanently.
Fellow winger Lee Holmes is the only injury absentee after undergoing an operation on his injured ankle last month.