Tottenham manager Harry Redknapp will rest several of his first-team regulars for Sunday's game against the Addicks.
Back-up players Vedran Corluka, Sebastien Bassong, Niko Kranjcar, Sandro and Wilson Palacios are likely to play while Jermain Defoe could start after missing the last three games through suspension.
Gareth Bale will be rested after picking up a minor back injury against Everton, Younes Kaboul is banned, and Carlo Cudicini (shoulder), Tom Huddlestone (ankle), Ledley King (groin), Jamie O'Hara (back) and Jonathan Woodgate (groin) are also unavailable.
Paul Benson will miss Charlton's clash with Tottenham as he begins a three-match ban in what will be Keith Peacock's first game in temporary charge.
Striker Benson lost his appeal against his sending off in the closing stages of the Addicks' 3-3 draw with Colchester which allowed him to play in the home defeat to Swindon on Bank Holiday Monday.
However, young defender Matt Fry is available after he extended his loan from West Ham for another month.
Plymouth defender Marcel Seip has returned to Home Park following the end of his loan stint in south London, where he was an unused substitute five times.
Peacock was appointed caretaker manager following the sacking of Phil Parkinson on Tuesday in the wake of the heavy 4-2 defeat to the Robins.
Spurs (from): Gomes, Pletikosa, Hutton, Corluka, Dawson, Gallas, Bassong, Assou-Ekotto, Sandro, Palacios, Jenas, Bale, Lennon, Bentley, Modric, Dos Santos, Van der Vaart, Crouch, Pavlyuchenko, Keane, Defoe.