United were without several senior players including Rio Ferdinand and Ryan Giggs as they flew out to France.
Ferdinand has not played since injuring a calf before United's Premier League defeat at Wolves on February 5, and his fellow central defender Jonny Evans also misses the trip, having been battling an ankle problem.
That means Chris Smalling is in line to start alongside Nemanja Vidic in the heart of the United back four against the French giants.
Veteran midfielder Giggs is another absentee from the United party, which is also missing Michael Owen, who has a groin injury.
United midfielder Anderson is a non-traveller and could be facing a lengthy absence from the side after being substituted at half-time in Saturday's FA Cup fifth-round win over Crawley.
He reportedly suffered a knee injury which will need further examination before United can be sure how long he will be absent for.
However United manager Sir Alex Ferguson is able to include Brazilian twins Rafael and Fabio, despite the pair both coming off with injuries during the Crawley match, while youngsters Joshua King and Ryan Tunnicliffe are also selected, along with Gabriel Obertan and Bebe.
United (from): Van der Sar, Kuszczak, Lindegaard; Vidic, O'Shea, Brown, Rafael, Fabio, Evra, Smalling, Scholes, Gibson, Nani, Carrick, Fletcher, Bebe, Obertan, Tunnicliffe, Rooney, Berbatov, Hernandez, King.