Watford are waiting on the fitness of winger Will Buckley.
The former Rochdale man picked up an ankle injury after a heavy challenge during the 3-1 defeat to North End's rivals Burnley at the weekend and is receiving treatment.
Buckley is unlikely to play but Don Cowie could return in his place after a spell out with a thigh injury.
Popular full-back Lloyd Doyley also missed the game on Saturday with his hamstring injury but has a chance of returning.
Youngster Michael Bryan is still missing with an ankle injury, but midfielder Ross Jenkins is back after struggling with a tight hamstring.
The Hornets have not won in their last five games in all competitions.
Preston boss Phil Brown looks set to persist with on-loan Everton goalkeeper Iain Turner between the posts.
Brown axed regular number one Andy Lonergan and replaced him with new recruit Turner for Saturday's 1-0 defeat at Hull.
Brown said: "Iain Turner played well enough for me. He obviously knows the challenge and is over the moon at the opportunity of playing first-team football."
Rookie defender Conor McLaughlin suffered a fracture to his left fibula and a dislocated ankle in the recent defeat to Bristol City and faces several months on the sidelines.
Striker Iain Hume could remain sidelined with a hamstring strain as Brown bids to guide North End to their first win since he took the reins last month.