Walsall boss Dean Smith hopes to have Jon Macken and Emanuel Ledesma available.
Striker Macken missed Saturday's 0-0 draw against Rochdale with a back spasm but should be fit to return.
Argentine attacking midfielder Ledesma joined the club last week as a free agent on a deal until the end of the season but is still waiting for international clearance to be granted.
Veteran forward Darren Byfield made his return after more than five months out with a knee injury against Dale, coming on as a 75th-minute substitute and he is expected to start on the bench again.
Cypriot midfielder Tom Williams made his first appearance for the club against Dale, playing the full 90 minutes, and after impressing he is expected to keep his place.
Southampton will hand Guly do Prado a late fitness check.
The Brazilian frontman had to be substituted an hour into Saturday's 4-1 win over Swindon after picking up a knock.
Lee Barnard replaced Guly and scored Saints' fourth goal to push his claims for a return to the starting line-up.
Defender Dan Seabourne and forwards Jonathan Forte and David Connolly sat out at the weekend with minor niggles and could feature but full-back Ryan Dickson remains doubtful with a neck injury.
Winger Lee Holmes is recovering from an ankle operation, and back-up goalkeeper Bartosz Bialkowski has a knee injury which may require surgery meaning Arsenal loanee James Shea will be on the bench again.