Carlo Ancelotti has refused to confirm whether Fernando Torres, Didier Drogba or both would lead the Chelsea attack in the game.
Ancelotti must decide whether to recall Drogba after the striker once again started on the bench in last week's Champions League win at FC Copenhagen.
David Luiz returns to the squad after being ineligible for the last two matches but Alex (knee) and Yossi Benayoun (Achilles) are still sidelined.
Wayne Rooney has been cleared to play for the league leaders on their trip to west London.
Rooney has escaped further punishment after catching Wigan's James McCarthy in the head with his elbow at the DW Stadium at the weekend.
Ryan Giggs is battling to overcome a hamstring strain but Sir Alex Ferguson said on Saturday that none of his other walking wounded, including Rio Ferdinand, will be available for the Premier League leaders.
Chelsea (from): Cech, Bosingwa, Ferreira, Terry, Luiz, Ivanovic, Zhirkov, Cole, Mikel, Essien, Lampard, Ramires, McEachran, Kalou, Malouda, Anelka, Torres, Drogba, Turnbull.
Manchester United (from): Van der Sar, Kuszczak, Lindegaard, O'Shea, Rafael, Smalling, Vidic, Brown, Evra, Fabio, Nani, Carrick, Fletcher, Scholes, Gibson, Giggs, Rooney, Berbatov, Hernandez, Bebe, Obertan.