Bournemouth boss Lee Bradbury will include Jayden Stockley in his squad.
The 17-year-old has been recalled from a loan spell at non-league side Dorchester Town due to the lack of attacking options at Bradbury's disposal following Ben Williamson's ankle injury.
Williamson has been ruled out for three weeks after sustaining the injury in training last week.
Left-back Rhoys Wiggins, who recently returned from a thigh injury, was taken off against Huddersfield on Saturday due to cramp but will be fit to start against Wednesday, while in-form striker Michael Symes will also retain his place despite suffering a facial injury.
Midfielder Mark Molesley is edging closer to his long-awaited return following an 18-month lay-off due to a foot injury.
The club's other long-term absentee, striker Steve Lovell, is some way off fitness having only just started running in straight lines following an ankle problem.
Sheffield Wednesday striker Gary Madine is expected to return to the starting line-up.
Madine was ineligible for Saturday's FA Cup defeat at Birmingham and, therefore, replaced by Neil Mellor.
Owls manager Gary Megson is also likely to make changes after overseeing his third straight defeat in charge of the club over the weekend.
Megson blamed his latest loss on defensive errors and, thus, is expected to make a few changes, although Jon Otsemobor (calf) and Lewis Buxton (hamstring) both remain sidelined and midfielder Giles Coke sits out the second of a three-game ban.
Richard Hinds is pushing for a recall to the back four and could return at either centre-half or right-back, while teenage midfielder Liam Palmer may make his first senior start for the club after an impressive second-half performance at Birmingham.