Wolves skipper Karl Henry and central defender Jody Craddock will return to the starting line-up after lengthy injury lay-offs for the clash.
Midfielder Henry made his comeback after a two-month lay-off with a knee injury as a substitute against Manchester City at Eastlands on Saturday.
Craddock has been sidelined with a hip problem since mid-October.
Midfielder David Edwards is still unavailable with a hamstring injury and full-back George Elokobi serves the second game of a three-match ban.
Doncaster will be without new loan signing Matt Kilgallon for game.
Kilgallon made his debut on Saturday in the home defeat to Reading after arriving on loan from Sunderland until the end of the season.
Another on-loan defender, Southampton's Joseph Mills, is doubtful due to a knee injury that forced him out of Saturday's 3-0 defeat.
If Mills fails to make it George Friend will make his first start since the win at Scunthorpe in mid-October, while O'Driscoll could be tempted to recall right-back James Chambers to his back line and revert to a 4-4-2 formation.
Otherwise, O'Driscoll has no other new injury or suspension problems as his side bid to reach the fourth round for the third successive year.
Wolves (from): Hennessey, Hahnemann, Zubar, Stearman, Craddock, Berra, Mouyokolo, Ward, Henry, Jarvis, Jones, Milijas, Hunt, Fletcher, Doyle, Doherty, Mujangi Bia, Davis, Vokes.