Wojciech Szczesny will again be in goal for the Gunners as Lukasz Fabianski remains sidelined with a shoulder problem.
Right-back Bacary Sagna is available after completing a three-match ban and winger Tomas Rosicky is expected back after a virus. Midfielder Aaron Ramsey could make his first Gunners appearance since recovering from a broken leg, while Nicklas Bendtner may get another chance in attack.
Defender Sebastien Squillaci (hamstring), midfielder Abou Diaby (calf), goalkeeper Manuel Almunia (ankle) and centre-back Thomas Vermaelen (Achilles) remain out.
Leeds striker Luciano Becchio is doubtful due to a back injury.
Becchio, who has scored 13 goals this season, was forced out of Saturday's 4-0 home win over Scunthorpe early in the second half and replaced by Billy Paynter.
Paynter, Davide Somma, also on target against Scunthorpe, and Ross McCormack all provide manager Simon Grayson with alternative options if Becchio fails to make it.
Left-back George McCartney is unavailable as he did not return to Leeds on loan for the rest of the season from Sunderland until after the 1-1 draw at the Emirates Stadium, so Ben Parker could return to the starting line-up.
Grayson has no other new injury or suspension worries, while Sanchez Watt, who fired his first goal for Leeds on Saturday, is hoping to face his parent club again after being given permission to play in the initial tie.
Arsenal (from): Szczesny, Gibbs, Djourou, Koscielny, Sagna, Fabregas, Denilson, Wilshere, Ramsey, Arshavin, Bendtner, Shea, Eboue, Song, Nasri, Van Persie, Clichy, Walcott, Vela, Chamakh, Miquel, Rosicky.