Manchester City boss Roberto Mancini is preparing to make big changes for the game.
As new signing Edin Dzeko is ineligible due to his transfer being completed after the deadline to play in the first tie at the Walker's Stadium, Brazilian forward Jo comes into the reckoning.
Shay Given, Joleon Lescott, James Milner, Patrick Vieira and David Silva are also set to start as City try to book a fourth-round trip to Notts County.
Ayegbeni Yakubu is ineligible for Leicester.
The loan signing from Everton, who marked his debut with a goal at Preston on Saturday, was not with the Foxes for the initial tie eight days ago and therefore cannot feature at Eastlands.
With Darius Vassell carrying a knock, Steve Howard could lead Leicester's attack against the joint-leaders of the Premier League.
Vassell's possible absence aside, Sven-Goran Eriksson could name the same side that drew 2-2 with big-spending City at the Walkers Stadium.
Eriksson will be making his first return to Eastlands since he was sacked as manager of Manchester City in the summer of 2008.
With Notts County awaiting the winner in round four, the Swede will be looking to set up another return to a former club. Eriksson was director of football at Notts last season.
Manchester City (from): Hart, Given, Zabaleta, Boateng, K Toure, Kompany, Boyata, Kolarov, Lescott, Wright-Phillips, Johnson, De Jong, Vieira, Milner, Y Toure, Silva, Barry, Tevez, Adebayor, Jo.