Rangers boss Walter Smith has defensive worries ahead of the game.
Stopper Madjid Bougherra is suspended while right-back Steven Whittaker is a doubt with a badly bruised toe as is left-back Sasa Papac, who has has a groin complaint.
Andy Webster and Richard Foster are set to come in to a side which could again be missing midfielder Steven Naismith who is struggling with a hamstring problem.
Inverness have no fresh concerns ahead of the game.
David Proctor was an unused substitute in last Saturday's 0-0 draw at Motherwell following a knee injury.
Jonny Hayes has returned to light training, but Gavin Morrison, Kenny Gillet and Kevin McCann remain out.
Rangers (from): McGregor, Whittaker, Papac, Foster, Weir, Davis, Edu, McCulloch, Ness, Weiss, Wylde, Naismith, Lafferty, Miller, Beattie, Jelavic, Webster, Alexander, Fleck.
Caley (from): Esson, Tokely, Munro, Cox, Proctor, Shinnie, Duff, Ross, Foran, Rooney, Odhiambo, Sutherland, Golabek, Tuffey, Duncan, Sanchez, Innes, Blumenshtein, Proctor.