Sheffield Wednesday will be without midfielder Tommy Miller and Gary Madine for the meeting with Hereford.
Miller is out for up to six weeks due to a hamstring problem and Madine is cup-tied.
Owls manager Alan Irvine will choose between Clinton Morrison and Paul Heffernan to partner Neil Mellor.
But Wednesday will be boosted by the return to contention of versatile defender Lewis Buxton, who has also been sidelined with a hamstring injury.
Fellow defender Jon Otsemobor is still missing with calf trouble and teenage midfielder Liam Palmer is struggling with an ankle problem.
Hereford are not expected to make any changes as they travel to Hillsborough bidding to make the fifth round of the FA Cup for the first time in their history.
Manager Jamie Pitman made just one enforced switch for Tuesday's 2-1 victory over Morecambe, with Birmingham loanee Jake Jervis coming in for star striker Mathieu Manset following his departure for Reading.
And having seen his side clock up a fifth successive win, Pitman is likely to keep the faith at Hillsborough.
Full-back Ryan Green returned from suspension to take his place on the bench in midweek and will be involved again, but long-term absentees Ryan Valentine and Dan Connor (both hip) continue to miss out.
More than 1,500 Bulls fans are expected to make the trip to Yorkshire to cheer on a Hereford side who have made it through to the fourth round having finally seen off Lincoln and then Wycombe in quick succession three weeks ago.