Scunthorpe boss Ian Baraclough will be without Joe Garner for the game.
The striker is on loan at Glanford Park from Forest and is ineligible to face Billy Davies' men under the terms of the deal.
Garry Thompson will also be missing after he underwent groin surgery last week but Chris Dagnall, Rob Jones and David Mirfin could return to Baraclough's plans.
The Iron have won only once at Glanford Park this season and that victory came back in August.
They now face three successive home games against Forest, Derby and Sheffield United.
"We've got three games coming up at home now which will shape our season," said Baraclough.
Nottingham Forest boss Billy Davies will be without midfielder Radoslaw Majewski, who begins a three-match suspension following his straight red card in the 1-1 draw at QPR on Sunday.
Davies fears injuries and suspensions could take their toll on his threadbare squad, and ultimately the club's promotion challenge.
The Scot is still unable to call upon Dexter Blackstock due to a knee injury and Robbie Findley and Guy Moussi, who are both nursing thigh complaints.
He said: "Radi is now going to be out for three games, which is a massive blow. How many central midfield players have we got now? We have two left."