Daniel Sturridge is set to make his Bolton debut after signing on loan from Chelsea on Monday.
The striker will provide competition for Kevin Davies and Johan Elmander, while fellow January signing David Wheater could make his Premier League bow for the club after playing in the FA Cup draw with Wigan at the weekend.
Lee Chung-yong also comes into contention after returning from Asian Cup duty with South Korea, with Stuart Holden and Gary Cahill likely to be recalled after being rested in the cup.
Wolves newcomer Jamie O'Hara is included in the squad for the clash.
O'Hara has joined Wolves on loan from Tottenham for the remainder of the season after recovering from a long-term back problem. His last senior appearance was in the FA Cup final when on loan to Portsmouth.
Fellow midfielder Stephen Hunt will be sidelined for two to three weeks with a calf injury suffered in Sunday's FA Cup clash against Stoke, but striker Kevin Doyle has recovered from illness.
Bolton (from): Bogdan, Jaaskelainen, Robinson, Cahill, Knight, Wheater, Muamba, Petrov, K Davies, Elmander, Klasnic, Taylor, Ricketts, Alonso, Moreno, M Davies, Cohen, Holden, Steinsson, Blake, O'Halloran, Sturridge, Lee.
Wolves (from): Hennessey, Hahnemann, Elokobi, Stearman, Henry, Fletcher, Ward, Berra, Jarvis, O'Hara, Milijas, Zubar, Edwards, Craddock, Ebanks-Blake, Doyle, Jones, Vokes, Mouyokolo, Foley.