Blackpool captain Charlie Adam will lead the side out at home to the Hammers after failing to secure a move in the January transfer window.
Manager Ian Holloway strengthened his squad by bringing in four players on deadline day and must decide which, if any, to involve against the Hammers.
That quartet are strikers James Beattie and Sergei Kornilenko plus midfielders Andy Reid and Jason Puncheon.
Holloway will hope to have left-back Stephen Crainey in contention again after he missed last week's home defeat by Manchester United with an ankle injury.
Meanwhile, new signings Robbie Keane, Demba Ba and Gary O'Neil are all in contention to make their Hammers debuts at Blackpool.
Victor Obinna is likely to retain his place after netting a hat-trick in the FA Cup win over Nottingham Forest after his return from suspension, meaning Carlton Cole could have to be content with a place on the bench.
Manuel Da Costa (ankle) and Thomas Hitzlsperger (thigh) remain sidelined.
Blackpool (from): Kingson, Eardley, Cathcart, Evatt, Adam, Phillips, Vaughan, Varney, Taylor-Fletcher, Campbell, Sylvestre, Grandin, Euell, Beattie, Reid, Puncheon, Kornilenko, Ormerod, Edwards, Baptiste, Rachubka.
West Ham (from): Green, Bridge, Upson, Tomkins, Jacobsen, O'Neil, Parker, Noble, Obinna, Keane, Piquionne, Boffin, Cole, Ba, Gabbidon, Ilunga, Spector, Kovac, Boa Morte, Barrera, Dyer, Hines.