Goalkeeper Manuel Almunia will return to the Arsenal squad for the first time since the end of September for the clash after recovering from elbow and then ankle injuries.
Full-back Bacary Sagna will be rested after suffering a clash of heads during the midweek Carling Cup semi-final second leg against Ipswich, but defender Sebastien Squillaci (hamstring), midfielders Abou Diaby (ankle) and Tomas Rosicky (virus) all return.
Lukasz Fabianski (shoulder) remains out, while centre-back Thomas Vermaelen (Achilles) is still some six weeks away from a possible return.
Teenage striker Benik Afobe, 17, is on loan at Huddersfield, but is not eligible to play against his parent club.
Huddersfield's leading goalscorer, Jordan Rhodes, will miss the game after being ruled out for eight weeks with ankle ligament damage, so Alan Lee and Lee Novak are set to lead the line, although Arsenal youngster Benik Afobe provides another option.
Loan defender Tamas Kadar misses out due to a hamstring injury, joining Gary Naysmith (toe) and Damien Johnson (knee) on the sidelines.
Arsenal (from): Almunia, Gibbs, Squillaci, Djourou, Eboue, Arshavin, Denilson, Diaby, Rosicky, Bendtner, Chamakh, Szczesny, Clichy, Song, Wilshere, Fabregas, Van Persie, Nasri, Walcott, Koscielny.