Dagenham goalkeeper Tony Roberts will make his 500th competitive appearance for the club.
The 41-year-old made his debut away to Leigh RMI in August 2000 and will be between the posts as John Still's men look to achieve survival.
On-loan Bristol City striker John Akinde will make his first start for the club alongside Bas Savage in attack.
Akinde made his long-awaited debut at Exeter on Saturday after nearly three months on the sidelines with a groin problem and will start as Oliver Lee misses out.
Midfielder Solomon Taiwo is out with an ankle injury so Peter Gain will continue to partner Romain Vincelot in the centre.
The Frenchman - converted from full-back by Still this year - scored his 11th goal of the season at the weekend.
Mark Little will return for Peterborough.
The right-back missed the 3-3 draw with Bournemouth on Friday night through suspension after he was sent-off at Bristol Rovers, but he will come into Darren Ferguson's side.
Utility-man Charlie Lee filled in at full-back on Friday night but should return to central midfield.
Goalkeeper Joe Lewis was at fault for two goals in the six-goal thriller but Ferguson will keep faith with the former England Under-21 man as Posh look for a vital win in their quest for promotion.
Midfielder Lee Frecklington has had a hernia operation and will be sidelined for several more weeks.
Striker Dave Hibbert is absent as he steps up his comeback from a dislocated knee suffered back in November.