Thomas Sorensen will replace Asmir Begovic in goal for Stoke.
Sorensen has played all three of Stoke's FA Cup games to date this season, and so retains his place on that basis as promised by manager Tony Pulis.
Pulis' only doubt is Matthew Etherington with a hamstring problem. Andy Wilkinson is likely to return at right back after being rested for last week's 1-0 defeat at Birmingham.
Chris Wood and Matt Sparrow should be in the Brighton squad.
On-loan West Brom striker Wood was substituted early on during last Saturday's 4-1 win over Hartlepool with a foot injury and midfielder Sparrow has missed two games with a knee problem, but both players returned to training on Thursday.
Bulgarian midfielder Radostin Kishishev is out for personal reasons, winger Craig Noone is cup-tied and Jim McNulty (ankle), Jamie Smith (foot) and Alan Navarro (cruciate) are long-term absentees.
Goalkeeper Peter Brezovan has played in all the previous rounds and is set to come in for regular number one Casper Ankergren again.
Albion are bidding to reach the last eight for only the third time in the club's history.
Stoke (from): Sorensen, Huth, Wilson, Delap, Etherington, Whitehead, Jones, Faye, Collins, Fuller, Pugh, Whelan, Pennant, Wilkinson, Walters, Carew, Shawcross, Begovic, Nash.