Birmingham boss Alex McLeish will ring the changes for the tie against the Owls.
Defenders Martin Jiranek and Liam Ridgewell are unlikely to be risked after suffering thigh and calf injuries respectively against Newcastle in midweek although both should be fit for the Carling Cup final against Arsenal a week on Sunday.
McLeish will hand a late fitness test to centre-back Curtis Davies who suffered a knee injury in training.
The likes of Kevin Phillips, Matt Derbyshire, Alexander Hleb, Lee Bowyer, Keith Fahey, Stuart Parnaby, David Murphy, Jordon Mutch and Colin Doyle are all in contention to face the Owls.
Sheffield Wednesday will be without suspended midfielder Giles Coke and striker Gary Madine.
Coke was shown a straight red card in the midweek defeat at Tranmere and sits out the first of a three-match ban, so Chris Sedgwick is expected to be recalled to midfield for the fifth-round tie.
Madine, a recent permanent signing from Carlisle, is not eligible having already appeared for the Cumbrians in the competition. Neil Mellor is hoping to step in alongside fellow forward Clinton Morrison.
Lewis Buxton missed out in midweek with a hamstring problem and fellow defender Jon Otsemobor remains sidelined with a calf injury, leaving manager Gary Megson with a big hole to fill at right-back.
Isaiah Osbourne, on-loan from Aston Villa, is eligible and Tommy Miller could return to the squad after missing the last six games due to a hamstring injury.
Fellow midfielder Darren Potter could return after missing out in midweek through illness.
Birmingham (from): Foster, Doyle, Carr, Parnaby, Johnson, Kerr, Davies, Murphy, Larsson, Fahey, Bowyer, Ferguson, Gardner, Bentley, Mutch, Hleb, Beausejour, Jerome, Zigic, Phillips, Martins, Derbyshire, Ridgewell, Jiranek.