West Ham will give a debut to Thomas Hitzlsperger.
The midfielder is yet to make an appearance for the Hammers after suffering a serious thigh injury while playing for Germany last summer, but is now near full fitness after coming through a series of reserve games.
The fitness of James Tomkins (calf) and Matthew Upson (Achilles) will be assessed over the weekend after they both missed last week's 3-3 draw at West Brom but Robbie Keane is out with a calf injury.
Burnley defender David Edgar could feature in the game after his loan move to Swansea collapsed because of red tape.
Recent signings Charlie Austin and Marvin Bartley are both cup-tied and Clarets boss Eddie Howe may call on Edgar's services.
He said: "David is back with us so we are pleased to have him back in the squad.
"With two lads dropping out it will be good to have him around."
Martin Paterson could be out for the rest of the season following the recurrence of a thigh injury and midfielder Chris McCann also remains sidelined.
West Ham (from): Green, Jacobsen, Gabbidon, Reid, Tomkins, Bridge, Upson, Faubert, O'Neil, Noble, Parker, Obinna, Boa Morte, Hitzlsperger, Piquionne, Kovac, Ilunga, Boffin, Cole, Sears, Ba.