Dundee United will be without winger Craig Conway for the SPL visit of the Accies.
The Scotland international has strained a thigh muscle but is expected to return for Sunday's Scottish Cup quarter-final with Motherwell.
His place in the side will be taken by David Robertson, while Danny Swanson will continue in midfield.
Paul Dixon returns after a virus, but striker Jon Daly remains out following a hernia operation along with knee injury victim Garry Kenneth.
Long-term victims Darren Dods (knee) and Scott Severin (ankle) are also absent.
Hamilton skipper Alex Neil is back in the squad for the trip to Tannadice.
The midfielder's season has been blighted with a hip injury and his last game was against Motherwell in October, but he has now fully recovered and will make the trip to Tayside.
Accies will field a similar side to the one which lost 2-0 to Celtic at Parkhead.
Dundee United (from): Pernis, Watson, Dixon, Dillon, Van der Meulen, Douglas, Gomis, Buaben, Swanson, S Robertson, D Robertson, Goodwillie, Russell, Shala, Kovacevic, Armstrong, Smith, Banks.
Hamilton (from): Cerny, Elebert, McLaughlin, Neil, McDonald, Carrington, Gillespie, Mensing, McAlister, Routledge, Imrie, Flavio Paixao, Crawford, Hasselbaink, Hopkirk, Murdoch, Antoine-Curier, Skelton, Graham.