Louis Saha is in contention for the Toffees after escaping unharmed from a car crash on Sunday night.
The only issue is whether the French striker is still troubled by the hamstring injury which hindered his return to action in Saturday's victory over Sunderland.
Midfielder Marouane Fellaini is a major doubt after aggravating an ankle problem against the Wearsiders.
Everton will also check on the fitness of Jermaine Beckford (groin), Tim Cahill (foot) and Victor Anichebe.
Reading captain Ivar Ingimarsson is set to miss out on the cup trip to face the Toffees.
The Icelandic centre-half came off with a groin injury during the 3-3 draw at Crystal Palace on Saturday and is set to miss out on the fifth-round clash at Goodison Park.
Alex Pearce remains sidelined with his thigh strain so former Blackburn man Zurab Khizanishvili is in line to start.
Right-back Andy Griffin missed out at the weekend with an Achilles injury, meaning Shaun Cummings will deputise once more.
Goalkeeper Adam Federici remains out with a knee injury so 21-year-old Alex McCarthy will continue fresh from saving a penalty against Palace.
Striker Mathieu Manset is a doubt with a calf injury but top scorer Shane Long is fit to lead the line and will hope to emulate his winning goal across Stanley Park at Anfield in last season's FA Cup run.
Everton (from): Howard, Neville, Jagielka, Distin, Baines, Coleman, Fellaini, Osman, Rodwell, Cahill, Arteta, Saha, Beckford, Bilyaletdinov, Gueye, Heitinga, Hibbert, Baxter, Duffy, Mucha.