City duo David Silva and Micah Richards could return to the side.
Silva missed the draw with Fulham because of an ankle injury while Richards was absent with a calf problem.
However, manager Roberto Mancini will again be without Vincent Kompany (hip), Nigel de Jong (ankle), Adam Johnson (ankle) and goalkeeper Shay Given (shoulder).
Aston Villa full-back Nathan Baker has been ruled out.
The 19-year-old is still suffering from concussion after a collision with Blackburn goalkeeper Paul Robinson on Saturday.
Fabian Delph, who replaced Baker, may again deputise as Ciaran Clark will be required to play at centre-back with Carlos Cuellar (hamstring) and James Collins (calf) still ruled out and Darren Bent is cup-tied.
Midfielder Jean Makoun is again suspended after his red card against Blackpool at Bloomfield Road.
Aston Villa (from): Friedel, Walker, Dunne, Clark, Delph, Albrighton, Reo-Coker, Pires, Downing, Young, Marshall, Petrov, Bradley, Bannan, Herd, Heskey, Agbonlahor, Delfouneso.
Man City (from): Hart, Taylor, Richards, Zabaleta, Boateng, K Toure, Kolarov, Lescott, Wright-Phillips, Vieira, Y Toure, Silva, Barry, Tevez, Dzeko, Balotelli, Jo, Boyata, M Johnson, Guidetti, Wabara.