Arsenal striker Robin van Persie is out for three weeks with a knee injury so will miss the replay with Orient.
Cesc Fabregas (hamstring), Theo Walcott (ankle), Laurent Koscielny (hamstring) and Alex Song (knee) have also been ruled out against Orient.
Manuel Almunia will start in goal with Wojciech Szczesny on the bench. Midfielder Abou Diaby is expected to start.
Leyton Orient's FA Cup hero Jonathan Tehoue has recovered from his migraine and will be fit.
Captain Steve Dawson has an outside chance of playing after it emerged that the knee injury he suffered against Huddersfield is not as bad as first feared, but Harry Kane is suspended after being sent off in the same match.
Ryan Jarvis and Moses Odubajo are cup-tied while there are doubts over Matthew Spring (calf) and Jimmy Smith (hamstring).
One bit of good news for Russell Slade's side is that Jason Crowe is available again after suffering no ill-effects on his ankle injury in training
Arsenal (from): Szczesny, Sagna, Djourou, Clichy, Nasri, Wilshere, Rosicky, Arshavin, Almunia, Gibbs, Eboue, Denilson, Chamakh, Bendtner, Squillaci, Diaby.
Orient (from): Jones, Omozusi, Whing, Chorley, Forbes, Cox, Dawson, McGleish, Chambers, Revell, Butcher, Daniels, Porter, Spring, Crowe, Tehoue, Cestor, Smith, Argent, Carroll, Millwood, Walker, M'Poku, Benjamin.