Arsenal could welcome back goalkeeper Wojciech Szczesny from a finger injury.
Centre-half Johan Djourou (shoulder) may also recover, along with midfielders Alex Song (knee) and Denilson (toe), but full-back Bacary Sagna (knee) is a doubt.
Goalkeeper Manuel Almunia (ankle) is also struggling so veteran Jens Lehmann could be set for a place on the bench again while Thomas Vermaelen (Achilles) continues his rehabilitation.
Teenager John Flanagan's tough baptism could continue as Liverpool travel to London without a number of key defenders.
The 18-year-old right-back made an impressive debut in Monday's Premier League win over Manchester City in the absence of Martin Kelly and Glen Johnson with hamstring injuries.
Brazilian Fabio Aurelio could continue at left-back after returning from a four-game absence, also with a hamstring problem, to face City.
Centre-back Daniel Agger (knee) and captain Steven Gerrard (groin) have both been ruled out for the rest of the season.
Arsenal (from): Szczesny, Eboue, Squillaci, Koscielny, Clichy, Song, Fabregas, Wilshere, Nasri, Arshavin, van Persie, Lehmann, Almunia, Walcott, Ramsey, Gibbs, Diaby, Bendtner, Chamakh, Rosicky, Djourou, Sagna.
Liverpool (from): Reina, Flanagan, Carragher, Skrtel, Aurelio, Kuyt, Lucas, Spearing, Meireles, Suarez, Carroll, Kyrgiakos, Wilson, Robinson, Cole, Rodriguez, Shelvey, Poulsen, Jovanovic, Ngog, Gulacsi.