Peter Crouch is available against the Gunners after returning from the suspension that ruled him out of Tottenham's Champions League clash against Real Madrid.
Steven Pienaar (groin) and Niko Kranjcar (foot) could play some part after making good progress in their injury treatment but Wilson Palacios and Alan Hutton (both knee) are still out.
Jonathan Woodgate (calf) and Ledley King (groin) have been training with Tottenham's fitness coaches but are unlikely to be involved in Wednesday's match.
Arsenal full-back Bacary Sagna (knee) is set to return.
Goalkeeper Manuel Almunia (knee) has also been passed fit, along with midfielders Denilson (toe) and Tomas Rosicky (illness).
Centre-back Thomas Vermaelen continues his rehabilitation from an Achilles problem, but is not yet in first-team contention.
Tottenham (from): Gomes, Cudicini, Pletikosa, Corluka, Assou-Ekotto, Bassong, Gallas, Dawson, Kaboul, Lennon, Kranjcar, Pienaar, Huddlestone, Sandro, Modric, Jenas, Rose, Bale, Van der Vaart, Defoe, Pavlyuchenko, Crouch.
Arsenal: (from): Szczesny, Sagna, Koscielny, Djourou, Clichy, Diaby, Wilshere, Walcott, Fabregas, Nasri, van Persie, Almunia, Song, Squillaci, Arshavin, Gibbs, Chamakh, Bendtner, Eboue, Rosicky, Denilson.